New groundwork propose the reason of Hair loss - Health And ...

Male-pattern baldness may be the effect of a protein in the scalp, according to recent research that raises the possibility that drugs being tested for other uses might avoid hair loss. Bald spots had an excessive amount of a protein called ?Prostaglandin D2? or PGD2, according to a study in Science Translational Medicine. Merck trial and error treatment for facial flushing and Actelion allergy combination, both in late- stage studies, block the healthy proteins.

About eight out of ten white men experience some balding before the age of 70, according to the researchers. Rogaine and Propecia slow the loss, and some users see minor hair growth. Men could probably re-grow all their hair if the inhibiting healthy proteins is removed, said George, chairman of dermatology at the University of Pennsylvania?s Perelman School of Medicine within Philadelphia.

We really do think if you take away the inhibition, you get longer hair, George, a study author, said in a telephone interview. We don?t know if the follicles will return to their former lengths, he explained. The study was funded by grants from the National Institutes of Health, the Pennsylvania Department involving Health, and other medical groups.

The researchers looked at the genes in the scalp samples from five men, comparing the bald parts to the haired sections. They found higher expressions of the gene that produces PGD2 in the bald samples, compared to the spots with hair. To be able as a guide, they found in samples of 17 men with hair loss that PGD2 was three times higher in the bald spots than where hair has been growing. The scientists then used mice to exhibit that excessive PGD2 decreased follicles.

Previous work has demonstrated that the stem cells that create hair continue to be intact in bald men, Cotsarelis said. The follicles are there, though they look smaller and produce finer, shorter hair. Over time, the hair is so short it no longer passes the top of skin.

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